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MGMT Mouse anti-Human, Unlabeled, Clone: MT5.1, BD

Catalog No. BDB557045 Shop All BD Biosciences Products
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BDB557045 0.1 mg
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Catalog No. BDB557045 Supplier BD Biosciences Supplier No. 557045
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Description

Mouse Monoclonal Antibody

The repair of mismatched DNA is essential to maintaining the integrity of genetic information over time. The important role played by DNA repair enzymes is emphasized by the fact that they are highly conserved from bacteria to yeast to mammals. In bacteria, DNA repair involves the activity of repair enzymes including the MutL, MutH, and MutS proteins, as well as an enzyme originally identified in bacteria, and subsequently in all mammalian species, MGMT (methylguanine-DNA methyltransferase). Human MGMT is a 21kDa protein which protects cells from the mutagenic effect of alkylating agents, which add a methyl group to the O6 position of guanine in DNA, producing O6-methylguanine. While MGMT is generally ubiquitously expressed in mammalian cells, the expression levels within cell and tissue types can be quite variable. Certain tumor cell types have been identified which express neither MGMT protein or mRNA, despite the apparent normal expression of the MGMT gene. The variable expression of MGMT may be a factor in the susceptibility of cells and tissues to the mutagenic effects of alkylating agents. It has been suggested that methylation of cytosine in the MGMT gene and promoter region may correlate with the expression of the MGMT gene product. MGMT is observed at 21kDa on SDS-PAGE.

Host Species: Mouse
Clone: MT5.1
Isotype: IgG1
Cross Reactivity: Human

Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen MGMT
Applications Western Blot
Classification Monoclonal
Clone MT5.1
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Methylguanine-DNA Methyltransferase
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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