MIC A/B anti-Human, Unlabeled, Clone: 6D4, BD

Monoclonal Antibody

Supplier:  BD Biosciences 558032

Catalog No. BDB558032

Description

Monoclonal antibody 6D4 reacts with MICA and MICB, distant homologs of major histocompatibility complex class I proteins. They are highly glycosylated molecules of approximately 70kDa that are normally expressed in gut epithelium, are frequently associated with epithelial tumors and can be induced by some viral and bacterial infections. MIC are highly expressed on proliferating but not on quiescent epithelial cell lines, on which they can be heat-shock induced. MIC have similar functional and structural properties and are ligands for NKG2D, an activating receptor on most NK cells, CD8 T cells and ?d T cells. Expression of MIC has been observed on synoviocytes in rheumatoid arthritis and on epithelial cells in transplanted kidney and pancreas showing histological signs of rejection and or cellular injury.

Host Species: Mouse
Clone: 6D4
Isotype: IgG2a, κ
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: MIC A/B
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 6D4
• Conjugate: Unconjugated
• Immunogen: MICA transfected cells
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2a κ

For Research Use Only.