MKK3b Mouse, Unlabeled, Clone: 30, BD

Catalog No.	Quantity
BDB611216	50 μg

Catalog No. BDB611216 Supplier BD Biosciences Supplier No. 611216

Description

Mouse Monoclonal Antibody

Mitogen activated protein (MAP) kinase signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. Three groups of mammalian MAP kinases have been identified: the extracellular signal-regulated kinases (ERK), the c-Jun N-terminal kinases (JNK), and the p38 MAP kinases. The p38 MAP kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases MKK3 and MKK6, which are activated by a MAP kinase kinase kinase (MKKK). MKK3b, an alternatively spliced isoform of MKK3, contains an extra 29 N-terminal amino acids. Like MKK3 and MKK6, MKK3b specifically activates p38 MAPK and is more efficient than MKK3 in mediating downstream signaling events. Although MKK6 expression is limited, MKK3 and MKK3b are expressed in a wide range of cell types. MKK3, MKK3b, and MKK6 function as specific activators of p38 MAPK. However, they differ in their expression patterns and strength of kinase activity and, therefore, may differentially regulate p38 MAPK activation.

Host Species: Mouse
Clone: 30
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human MKK3b aa. 12-114
Formula Weight [Chemical]: 37kDa

Immunofluorescence, Western Blotting

Specifications

• Antigen: MKK3b
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 30
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Host Species: Mouse
• Immunogen: Human MKK3b aa. 12-114
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG2a