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matrix metallopeptidase 12 (macrophage elastase), Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against a full-length human MMP12 protein.
Supplier: Abnova Corporation H00004321D01P
Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Sequence: MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGCSpecifications
matrix metallopeptidase 12 (macrophage elastase) | |
Polyclonal | |
Rabbit polyclonal antibody raised against a full-length human MMP12 protein. | |
MMP12 | |
HME/MGC138506/MME | |
Rabbit | |
Affinity Purified | |
RUO | |
4321 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
Western Blot | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_002426 | |
MMP12 | |
MMP12 (NP_002417.2, 1 a.a. ∼ 470 a.a) full-length human protein. | |
100 μg | |
Primary | |
Human, Rat | |
Antibody |
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