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MMP13 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527242

Catalog No. PIPA527242


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Description

Description

PA5-27242 targets MMP13 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27242 immunogen is synthetic peptide corresponding to a region within amino acids 220 and 314 of Human MMP13. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
Specifications

Specifications

MMP13
Polyclonal
Unconjugated
MMP13
Liquid
MMP13
Synthetic peptide corresponding to a region within amino acids 220 and 314 of Human MMP13
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P45452
CLG3, MANDP1, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3)
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4322
Documents
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