MMP13 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527242
PA5-27242 targets MMP13 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27242 immunogen is synthetic peptide corresponding to a region within amino acids 220 and 314 of Human MMP13. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
|Synthetic peptide corresponding to a region within amino acids 220 and 314 of Human MMP13|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|CLG3, MANDP1, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3)|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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