anti-CD74, APC, Clone: LN2, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233088APC
DescriptionCD74 Monoclonal antibody specifically detects CD74 in Human, Mouse, Baboon, Rat (Negative) samples. It is validated for Flow Cytometry.
|SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody|
|Human, Mouse, Baboon, Rat (Negative)|
|PBS with 0.05% Sodium Azide|
|CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, DHLAGgamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, MHC HLA-DR gamma chain, p33|
|Protein G purified|
|Store at 4C in the dark.|
|It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+). This antibody can be used for the identification of B cell lymphoma and leukemias. It also stains activated neoplastic cells in T cell lymphomas and Sternberg-reed cells.|
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