anti-MRP2, Clone: M2III-6, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP142349

Catalog No. NBP142349

Description

MRP2 Monoclonal antibody specifically detects MRP2 in Human, Rat samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Specifications

• Antigen: MRP2
• Clone: M2III-6
• Conjugate: Unconjugated
• Formulation: Serum - free culture supernatant with 0.7% BSA with 0.1% Sodium Azide
• Format: Supernatant
• Gene Symbols: ABCC2
• Immunogen: The antibody reacts with the MRP2 antigen.
• Purification Method: Tissue culture supernatant
• Regulatory Status: RUO
• Storage Requirements: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Monoclonal or Polyclonal: Monoclonal
• Test Specificity: M2III-6 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-6 was raised against a bacterial fusion protein of cMOAB/MRP2, containing the 202-amino acid COOH terminal end of the protein. M2III-6 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.

• Applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Concentration: 0.25 mg/mL
• Dilution: Western Blot 1:20-1:50, Flow Cytometry 1:10-1:1000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:20-1:50, Immunohistochemistry-Paraffin 1:20, Immunohistochemistry-Frozen 1:20
• Gene Accession No.: Q92887
• Gene Alias: ATP-binding cassette, sub-family C (CFTR/MRP), member 2, Canalicular multidrug resistance protein, canalicular multispecific organic anion transporter 1, CMOAT1, CMOATABC30, CMRP, DJS, KIAA1010, MRP2ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2
• Host Species: Mouse
• Isotype: IgG2a
• Quantity: 0.2 ml
• Research Discipline: ABC Transporters, Amino Acids Drugs and other small molecules, Cancer, Diabetes Research, Lipid and Metabolism
• Primary or Secondary: Primary
• Gene ID (Entrez): 1244
• Target Species: Human, Rat

For Research Use Only