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Plasma Cell Marker Antibody (SPM310), Alexa Fluor™ 488, Novus Biologicals™
SDP

Catalog No. NBP234407X Shop All R&D Systems Products
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Catalog No. NBP234407X Supplier Novus Biologicals Supplier No. NBP234407AF488
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Description

Mouse Monoclonal Antibody

Plasma Cell Marker Monoclonal specifically detects Plasma Cell Marker in Human, Rat (Negative) samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Plasma Cell Marker
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM310
Conjugate Alexa Fluor 488
Dilution Immunohistochemistry-Paraffin
Host Species Mouse
Immunogen Pancreatic cancer-related mucin
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This monoclonal antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this monoclonal antibody is not suitable for staining frozen tissues.
Target Species Human, Rat (Negative)
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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