MRP-1 Mouse anti-Human, FITC, Clone: QCRL-3, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 557593

Catalog No. BDB557593

Description

Reacts with an intracellular epitope of the multidrug resistance protein (MRP1). MRP1 is a 190kDa integral membrane phosphoglycoprotein, member of the ATP-binding cassette transporter proteins, overexpressed in some drug-selected resistant cell lines and has been shown to cause multidrug resistance in transfected cells. Clone QCRL-3 was generated using non-denatured membranes from H69AR, an MRP1-overexpressing, multidrug resistant, drug-selected cell line. Its epitope has been localized to the first nucleotide binding domain of MRP1 between amino acids 617 and 932.3 QCRL-3 does not cross-react with human MDR1 or MDR3 gene products, nor with murine MRP1. It is reported that mAb QCRL-3 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles.

Host Species: Mouse
Clone: QCRL-3
Isotype: IgG2a, κ
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: MRP-1
• Classification: Monoclonal
• Conjugate: FITC
• Host Species: Mouse
• Quantity: 100 Tests
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: QCRL-3
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.