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MRP-1 Mouse anti-Human, FITC, Clone: QCRL-3, BD

Catalog No. BDB557593 Shop All BD Biosciences Products
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BDB557593 100 Tests
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Catalog No. BDB557593 Supplier BD Biosciences Supplier No. 557593
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Description

Mouse Monoclonal Antibody

Reacts with an intracellular epitope of the multidrug resistance protein (MRP1). MRP1 is a 190kDa integral membrane phosphoglycoprotein, member of the ATP-binding cassette transporter proteins, overexpressed in some drug-selected resistant cell lines and has been shown to cause multidrug resistance in transfected cells. Clone QCRL-3 was generated using non-denatured membranes from H69AR, an MRP1-overexpressing, multidrug resistant, drug-selected cell line. Its epitope has been localized to the first nucleotide binding domain of MRP1 between amino acids 617 and 932.3 QCRL-3 does not cross-react with human MDR1 or MDR3 gene products, nor with murine MRP1. It is reported that mAb QCRL-3 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles.

Host Species: Mouse
Clone: QCRL-3
Isotype: IgG2a, κ
Cross Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen MRP-1
Applications Flow Cytometry
Classification Monoclonal
Clone QCRL-3
Conjugate FITC
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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