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MilliporeSigma™ anti-MTA3 (400-450), Polyclonal

Catalog No. IM101250UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
IM101250UG 50 μg Unconjugated
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Catalog No. IM101250UG Supplier MilliporeSigma™ Supplier No. IM101250UG

Description

Rabbit Polyclonal Antibody

Specifically detects MTA3 (400-450) Clone: in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation

MTA1, MTA2, and MTA3 (Metastasis-associated gene 3, ACC# AAH53631) are members of a growing novel gene family associated with highly metastatic human carcinomas. MTA3 is expressed in all tissues as both 515 aa (MTA3) and 594 aa (MTA3L) proteins found in both the nucleus and the cytoplasmic compartments. It was identified as an Estrogen receptor (ER) regulated component of the Mi/NuRD histone deacetylase transcriptional repressor. In response to estrogen, MTA3 directly targets Snail, the master regulator of the epithelial to mesenchymal transition (EMT). Regulation of E-cadherin expression due to MTA3 and ER mediated signaling of Snail expression may be an important pathway in human breast tumors. Loss of ER results in decreased MTA3 expression and tamoxifen reduces expression of MTA3 in endometrial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTA3 (400-450)
Applications Immunocytochemistry, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
Formulation In Tris-citrate/phosphate buffer, pH 7.0-8.0.
Host Species Rabbit
Immunogen a synthetic peptide corresponding to amino acids within residues 400-450 of human MTA3
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽62kDa MTA3 protein in MCF-7 cells.
Target Species Human
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG
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For Research Use Only

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