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MTSS1 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523197

Catalog No. PIPA523197


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Description

Description

Metastasis suppressor protein 1 (MTSS1) [MIM, “missing in metastasis”], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains an actin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
Specifications

Specifications

MTSS1
Polyclonal
Unconjugated
MTSS1
Liquid
MTSS1
Synthetic peptide (684 EEHRQAIPESEAEDQERE 701) of MTSS1 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
O43312
MIM, MIMA, MIMB, metastasis suppressor YGL-1, metastasis suppressor protein 1, missing in metastasis protein
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9788
Documents
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