MBNL1, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Heidolph North America 015908402

Catalog No. 01-670-295

Description

Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.

Specifications

• Antigen: MBNL1
• Classification: Monoclonal
• Dilution: Assay dependent
• Gene Accession No.: Q9NR56, Q9JKP5
• Gene Symbols: MBNL1
• Immunogen: Recombinant human Muscleblind protein
• Regulatory Status: RUO
• Gene ID (Entrez): 282635, 4154, 56758
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: MBNL1
• Gene Alias: Muscleblind-like protein 1, MBNL
• Host Species: Mouse
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1 κ