MilliporeSigma™ anti-MxB, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABF1059

Catalog No. ABF1059MI

Description

Specifically detects MxB Clone: in Human samples, and it is validated for Western Blotting

Interferon-induced GTP-binding protein Mx2 (UniProt P20592; also known as Interferon-regulated resistance GTP-binding protein MxB, Myxovirus resistance protein 2, p78-related protein, Second interferon-induced protein p78) is encoded by the MX2 (also known as MXB) gene (Gene ID 4600) in human. The interferon-inducible myxovirus resistance (Mx) proteins belong to the family of large GTPases and are highly homologous with dynamins within their GTP-binding domain. MxA/Mx1 is cytosolic, while two MxB/Mx forms exist, a 78kDa nuclear form and a 76kDa cytosolic form lacking the N-terminal nuclear localization signal (NLS). Human MxA protein mediates resistance to influenza and several other viruses, while human MxB is also reported to inhibit HIV-1 infection by reducing the level of integrated viral DNA. In addition, HIV-1 with Ala88 mutation in the capsid protein (CA) is found to escape MxB restriction, as a result of impaired CA interaction with the host peptidylprolyl isomerase cyclophilin A (CypA). Likewise, CypA deletion results in the loss of MxB inhibition of HIV-1.

Specifications

• Antigen: MxB
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Symbols: MX2
• Immunogen: GST-tagged recombinant protein corresponding to the Dynamin-type G domain of human MxB.
• Quantity: 100 μL
• Research Discipline: Inflammation, Immunology
• Gene ID (Entrez): NP_002454
• Target Species: Human
• Form: Serum

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P20592
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Expected to react with both spliced isoforms.
• Content And Storage: −20°C for one year

For Research Use Only