MilliporeSigma™ anti-Myelin Basic Protein Clone: SMI-99,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ NE1019100UL

Catalog No. NE1019100UL

Description

Specifically detects Myelin Basic Protein Clone: SMI-99 in Guinea Pig samples, and it is validated for ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blotting

The myelin sheath is essential for rapid and effective propagation of action potential within the axon. Mutations identified in several myelin-related genes reportedly lead to severe demyelinating neuropathies. Recent evidence also suggests that the autoimmune disease Multiple Sclerosis (MS) is mediated by T cells with specificity for antigens in the myelin sheath. Although myelin in the central nervous system (CNS) and peripheral nervous system (PNS) is structurally similar, it is chemically distinct since oligodendrocytes form myelin in the CNS whereas Schwann cells generate PNS myelin. Myelin proteolipid protein (PLP) is the predominant integral membrane protein in mammalian CNS myelin. In contrast, myelin basic protein (MBP) is localized to the myelin cytoplasm and is highly conserved among species. Both MBP and PLP mediate myelin compaction, whereas thickness is regulated by MBP. Several other myelin proteins have been identified to play distinct or partially overlapping functions in the formation and maintenance of the myelin sheath, including P0, myelin-associated glycoprotein (MAG), peripheral myelin protein (PMP22), and Connexin 32 (Cx32). The development of the myelin sheath has been a good model for understanding the mechanisms of neuron-glia interaction.

Specifications

• Antigen: Myelin Basic Protein
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Guinea Pig
• Form: Purified

• Applications: ELISA, Immunoblot, Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: SMI-99
• Formulation: In PBS.
• Immunogen: human myelin basic protein
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽21kDa myelin basic protein in rat brain tissue. Does not recognize the 14kDa form. Recognizes most mammalian species.
• Content And Storage: −20°C
• Isotype: IgG2b

For Research Use Only