anti-MYLK, MaxPab™ Polyclonal, Abnova

Rabbit Polyclonal

Manufacturer: Abnova Corporation H00004638D01P

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Catalog No. 89-017-878

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    Antigen myosin light chain kinase
    Conjugate Unlabeled
    Cross Reactivity Human
    Format Affinity Purified
    Host Species Rabbit
    Immunogen MYLK (ENSP00000355024, 1 a.a. ∽992 a.a) full-length human protein.
    Purification Method Protein A column
    Quantity 100μg
    Regulatory Status RUO
    Research Discipline Kinases
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal

    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

    Host Species: Rabbit
    Species Reactivity [for Features Main]: Human
    Immunogen: MYLK (ENSP00000355024, 1 a.a. ~ 992 a.a) full-length human protein.

    Detection Antibody, Western Blotting

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