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MyoD Mouse, Unlabeled, Clone: MOAB 5.8A, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 554130

Catalog No. BDB554130


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Description

Description

MyoD is a member of a family of myogenic basic helix-loop-helix (bHLH) transcription factors that includes Myf-5, myogenin, and MRF4 (also known as herculin or Myf-6). Members of this family, expressed exclusively in skeletal muscle, play a key role in myogenesis by activating muscle-specific genes in response to extracellular growth factors. Transfection of MyoD and other family members into non-muscle cells has been shown to either convert these cells to myogenic cells or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. Members of this family have distinct roles in muscle development; for example, MyoD and Myf-5 act early during myeloid development, whereas myogenin acts at a later point during myoblast differentiation. The expression and activity of MyoD has been shown to involve the mitogen-activated protein kinase (MAPK) cascade.
This antibody is routinely tested by western blot analysis. The epitope for MoAb 5.8A has been mapped to amino acids 180-189 of mouse MyoD. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: MoAb 5.8A
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Recombinant Mouse MyoD
Formula Weight [Chemical]: 45/48kDa

Immunohistochemistry (Frozen), Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

MyoD
Monoclonal
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Recombinant Mouse MyoD
0.1 mg
Cell Biology
Chicken, Human, Mouse, Rat
IgG1 κ
Western Blot
MOAB 5.8A
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C
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