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MyoD Mouse, Unlabeled, Clone: MOAB 5.8A, BD

Catalog No. BDB554130 Shop All BD Biosciences Products
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Catalog No. BDB554130 Supplier BD Biosciences Supplier No. 554130
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Description

Mouse Monoclonal Antibody

MyoD is a member of a family of myogenic basic helix-loop-helix (bHLH) transcription factors that includes Myf-5, myogenin, and MRF4 (also known as herculin or Myf-6). Members of this family, expressed exclusively in skeletal muscle, play a key role in myogenesis by activating muscle-specific genes in response to extracellular growth factors. Transfection of MyoD and other family members into non-muscle cells has been shown to either convert these cells to myogenic cells or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. Members of this family have distinct roles in muscle development; for example, MyoD and Myf-5 act early during myeloid development, whereas myogenin acts at a later point during myoblast differentiation. The expression and activity of MyoD has been shown to involve the mitogen-activated protein kinase (MAPK) cascade.
This antibody is routinely tested by western blot analysis. The epitope for MoAb 5.8A has been mapped to amino acids 180-189 of mouse MyoD. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: MoAb 5.8A
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Recombinant Mouse MyoD
Formula Weight [Chemical]: 45/48kDa

Immunohistochemistry (Frozen), Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen MyoD
Applications Western Blot
Classification Monoclonal
Clone MOAB 5.8A
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Mouse MyoD
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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