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Nanog Mouse anti-Human, Unlabeled, Clone: N31-355, BD

Catalog No. BDB560482 Shop All BD Biosciences Products
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BDB560482 0.1 mg
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Catalog No. BDB560482 Supplier BD Biosciences Supplier No. 560482

Description

Mouse Monoclonal Antibody

The N31-355 monoclonal antibody reacts with human Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone Morphogenic Protein). When Nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53. Nanog is one of the factors that can contribute to reprogramming of differentiated cells to an induced pluripotent stem cell state.

Host Species: Mouse
Clone: N31-355
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Nanog Recombinant Protein

Bioimaging, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Nanog
Applications Western Blot
Classification Monoclonal
Clone N31-355
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Nanog Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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