NAT1 Mouse, Unlabeled, Clone: 35, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610742

Catalog No. BDB610742

Description

eIF-4 proteins are required for recognition of mRNA and acceleration of protein translation. This group of proteins consists of the RNA helicase eIF-4A, the RNA-binding protein eIF-4B, the cap-binding protein eIF-4E, and eIF-4G (p220). NAT1 (Novel APOBEC-1 Target no. 1), also known as DAP-5 (Death Associated Protein -5), is homologous to eIF-4G. Amino acid sequence comparison of NAT1 and eIF-4 shows that NAT1 lacks an eIF-4G N-terminal region. This region mediates eIF-4G association with eIF-4E. The highest degree of homology is
within the central portions of NAT1 and eIF-4G, while the lowest degree of homology occurs at the C-terminus. NAT1 more closely resembles a cleaved form of eIF-4G that is involved in cap-independent translation. It is thought that NAT1 is involved in the repression of translation via its inhibition of both cap-dependent and cap-independent translation.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

• Antigen: NAT1
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Novel APOBEC-1 Target no. 1; DAP-5; Death Associated Protein -5
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Immunofluorescence, Western Blot
• Clone: 35
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human NAT1 aa. 672-830
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Bovine, Canine, Human, Mouse, Rat
• Isotype: IgG1

For Research Use Only.