nicastrin, Mouse, Polyclonal Antibody, Abnova
Mouse polyclonal antibody raised against a partial recombinant NCSTN.
Manufacturer: Abnova Corporation H00023385A01
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeqSequence: VERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFS
|ELISA, Western Blot|
|Mouse polyclonal antibody raised against a partial recombinant NCSTN.|
|NCSTN (AAH47621, 16 a.a. ~ 115 a.a) partial recombinant protein with GST tag.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
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