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NDUFB8 Mouse anti-Bovine, Human, Mouse, Porcine, Rat, Clone: 20E9DH10C12, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 459210

Catalog No. 45-921-0


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Description

Description

Positive control: Isolated mitochondria from Human heart, bovine heart, rat heart and mouse heart. Skeletal muscle tissue.

Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyzes electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson’s disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.

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Specifications

Specifications

NDUFB8
Monoclonal
1 mg/mL
HEPES buffered saline with 0.02% sodium azide; pH 7.4
Q02372, O95169, Q9D6J5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 mitochondrial, Complex I-ASHI, CI-ASHI, NADH-ubiquinone oxidoreductase ASHI subunit
Mouse
IgG1, kappa
100 μg
4° C
Primary
282517, 293991, 4714, 67264
Immunohistochemistry, Western Blot
20E9DH10C12
Unconjugated
NDUFB8
Liquid
NDUFB8
Bovine Complex I
Ammonium Sulfate Precipitation
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Porcine, Rat
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