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Nedd4 Mouse anti-Mouse, Unlabeled, Clone: 15, BD

Catalog No. BDB611480 Shop All BD Biosciences Products
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Catalog No. BDB611480 Supplier BD Biosciences Supplier No. 611480
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Description

Mouse Monoclonal Antibody

Regulated protein degradation involves conjugation of ubiquitin to proteins for degradation by the 26S proteasome. Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1-E3. Neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) is a multimodular ubiquitin protein ligase E3 that contains a Ca2+;-lipid binding domain (CaLB), 3 WW domains, and a C-terminal ubiquitin protein ligase hect domain. The CaLB is characteristic of C2 domain-containing proteins, such as PKC, phospholipase C, phospholipase A2, and synaptogamin. Nedd4 is expressed differentially in the fetal and adult brain and its highest expression is in lung and kidney. Although it localizes in the cytoplasm, increased intracellular Ca 2+ induces plasma membrane association of Nedd4. In addition, increases in intracellular Na+ leads to Nedd4 binding to epithelial Na+ channels via its WW domains, which results in targeting of Na+ channels for degradation. Thus, the subcellular localization and protein interactions of Nedd4 are regulated in a Ca2+;- and Na+-dependent manner.

Host Species: Mouse
Clone: 15
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Mouse Nedd4 aa. 173-262
Formula Weight [Chemical]: 110kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Nedd4
Applications Western Blot
Classification Monoclonal
Clone 15
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse Nedd4 aa. 173-262
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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