MilliporeSigma™ anti-Neurophysin 2/NP-AVP Clone: PS 41,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN845

Catalog No. MABN845MI

Description

Specifically detects Neurophysin 2/NP-AVP Clone: PS 41 in Rat samples, and it is validated for Electron Microscopy, ELISA, Immunohistochemistry, Immunoprecipitation, Radioimmunoassay, Western Blotting

The neurophysin 1 and 2 (NPI and NPII) are carriers of peptide hormone oxytocin (OT) and vasopressin (AVP), respectively. Each NP and its associated hormone peptide are synthesized as one precursor protein, OT-NPI (UniProt P01179) encoded by the Oxt (or Ot) gene or AVP-NPII (UniProt P01186) encoded by the Avp gene in rat species. Post-translational cleavages remove the signal peptide and process the precursor into mature OT and NPI (aa 20-28 and aa 32-135, respectively, of OT-NPI) or AVP and NPII (aa 24-32 and aa 36-128, respectively, of AVP-NPII). OT is a potent hormone and neurotransmitter secreted within the pituitary gland. OT exerts its biological activity through its receptor OXTR (also known as OTR). OT is used clinically for labor induction and may exhibit therapeutic potential for treating social anxiety disorders. AVP functions primarily as an anti-diuretic and regulates the concentration of water, glucose, and salts in blood. AVP is secreted from the posterior pituitary, but exerts its biological activity in the kidney via the G protein-coupled receptor AVPR2 (V2R).

Specifications

• Antigen: Neurophysin 2/NP-AVP
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: P01186
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone PS 41 reacts with Vasopressin-neurophysin 2-copeptin precursor, neurophysin 2, but not Arg-vasopressin, copeptin, oxytocin, or neurophysin 1.
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG2b κ

• Applications: Immunoassay, ELISA, Immunohistochemistry, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
• Clone: PS 41
• Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: Avp
• Immunogen: KLH-conjugated acid soluble extract of rat (Sprague-Dawley) intermediate lobes.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_058688
• Target Species: Rat
• Form: Purified

For Research Use Only