NFKB1, Mouse, Clone: 4A11, Abnova™

Catalog No.	Quantity
89-123-247	100 μg

Catalog No. 89-123-247 Supplier Abnova Corporation Supplier No. H00004790M02

Description

Mouse monoclonal antibody raised against a partial recombinant NFKB1.

This gene encodes a 105kDa protein which can undergo cotranslational processing by the 26S proteasome to produce a 50kDa protein. The 105kDa protein is a Rel protein-specific transcription inhibitor and the 50kDa protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: MDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI

Specifications

• Antigen: NFKB1
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), In situ PLA, Western Blot
• Classification: Monoclonal
• Clone: 4A11
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant NFKB1.
• Formulation: PBS with no preservative; pH 7.4
• Gene: NFKB1
• Gene Accession No.: BC051765
• Gene Alias: DKFZp686C01211/EBP-1/KBF1/MGC54151/NF-kappa-B/NFKB-p105/NFKB-p50/p105/p50
• Gene Symbols: NFKB1
• Host Species: Mouse
• Immunogen: NFKB1 (AAH51765, 860 a.a. ∼ 969 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4790
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ