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MilliporeSigma™ anti-Nitrotyrosine, Alexa Fluor 647, Polyclonal

Catalog No. 06284AF647 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 647
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Catalog No. Quantity Conjugate
06-284-AF647 100 μL Alexa Fluor 647
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Catalog No. 06-284-AF647 Supplier MilliporeSigma™ Supplier No. 06284AF647
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Description

Rabbit Polyclonal Antibody

Specifically detects Nitrotyrosine Clone: in Human samples, and it is validated for Immunohistochemistry

Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species. Proteins are often targets of reactive species and detection of oxidatively modified proteins is often used as an index of oxidative stress. Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide. The reaction of proteins with peroxynitrite results in the oxidation of tryptophan and cysteine, as well as the nitration of tyrosine, formation of dityrosine, 2,4 dinitrophenylhydrazine-reactive carbonyls, and protein fragmentation. The formation of 3-nitrotyrosine represents a specific peroxynitrite-mediated protein modification that is different from modifications mediated by reactive oxygen species. Studies show that elevated nitrotyrosine levels are associated with inflammatory conditions, such as atherosclerotic plaques and rheumatoid arthritis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nitrotyrosine
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Alexa Fluor 647
Formulation Purified rabbit antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Host Species Rabbit
Immunogen Nitratred KLH.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Test Specificity Recognizes proteins which are nitrated.
Target Species Human
Content And Storage 2°C to 8°C for one year
Form Purified
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For Research Use Only

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