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NKG2D Mouse anti-Human, PE, Clone: 1D11, BD

Catalog No. BDB557940 Shop All BD Biosciences Products
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Catalog No. BDB557940 Supplier BD Biosciences Supplier No. 557940
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Description

Mouse Monoclonal Antibody

Antibody 1D11 reacts with CD314, also known as NKG2D (42kDa), an activating receptor for MICA encoded within MHC. Different from natural cytotoxicity receptor (NCR), CD314 expression is not confined to NK cells, it is also present on virtually all TCR γ/δ+ and CD8+TCR α/β+ T cells. CD314 functions as a triggering receptor involved in natural cytotoxicity mediated by normal NK cells against a variety of tumors or normal target cells. More importantly, CD314 can complement the role of NCR in tumor cell lysis. Remarkably, the combined maskings of NCR and CD314 led to a complete inhibition of NK-mediated lysis of all tumor or normal cells

Host Species: Mouse
Clone: 1D11
Isotype: IgG1, κ
Cross Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen NKG2D
Applications Flow Cytometry
Classification Monoclonal
Clone 1D11
Concentration 0.2mg/mL
Conjugate PE
Description CD314; KLRK1; KLR; NKG2D; NKG2-D; NK cell receptor D
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen NKL cells
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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