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Nkx2.2 Mouse, Unlabeled, Clone: 74.5A5, BD

Catalog No. BDB564731 Shop All BD Biosciences Products
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Catalog No. BDB564731 Supplier BD Biosciences Supplier No. 564731
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Description

Mouse Monoclonal Antibody

The 74.5A5 monoclonal antibody specifically binds to Homeobox protein Nkx-2.2 (Nkx2.2), which is a transcription factor required for the differentiation of ventral neuronal populations in the central nervous system and endocrine cell populations in the pancreas and intestine. Within the pancreas, Nkx2.2 is expressed in many cell subsets and plays important roles in islet and β- cell differentiation and maturation. Mice with a homozygous disruption of the Nkx2-2 gene lack mature β cells and die shortly after birth with severe hyperglycemia. Similarly to the Nkx2.2-ablated mice, homozygous mutations in the human NKX2-2 gene have been described in diabetic patients and associated with the etiology of neonatal diabetes. The NKX2-2 gene is also a target of the Ewing sarcoma specific protein EWS-FLI. Nkx2.2 expression can be monitored in order to determine cell fate changes in cultures for the generation of human pluripotent stem cell-derived insulin-producing cells as well as oligodendrocyte progenitors.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Nkx2.2
Applications Flow Cytometry
Classification Monoclonal
Clone 74.5A5
Concentration 0.5mg/mL
Conjugate Unconjugated
Description NKX2-2; NKX2B; Nkx2-2; Nkx-2.2; NK-2 homolog B; glycoprotein GP330
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Chicken Nkx2.2 Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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