Nkx6.1 Mouse, Unlabeled, Clone: R11-560, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 563022

Catalog No. BDB563022

Description

The R11-560 monoclonal antibody specifically binds to human and mouse homeobox protein Nkx6.1. The transcription factor Nkx6.1 plays a role in pancreatic islet beta cell development through the regulation of HNF1a and insulin genes. Nkx6.1 is considered to be a highly specific transcription factor marking pancreatic beta islet cells, where it is expressed in both developing and mature cells. In addition, Nkx6.1 functions as a transcriptional repressor induced by the Sonic Hedgehog (Shh) signaling pathway in fate determination of several neuronal cell types. During antibody development, the purified R11-560 monoclonal antibody was found to detect Nkx6.1 by western blot and indirect immunofluorescent staining followed by flow cytometric analysis or imaging analysis.

Specifications

• Antigen: Nkx6.1
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: Nkx6.1, NKX6-1, NKX6A, Nkx6-1, Nkx6.1, Nkx6a
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: R11-560
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human Nkx6.1 Recombinant Protein
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov