Nkx6.1 Mouse, Unlabeled, Clone: R11-560, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563022
The R11-560 monoclonal antibody specifically binds to human and mouse homeobox protein Nkx6.1. The transcription factor Nkx6.1 plays a role in pancreatic islet beta cell development through the regulation of HNF1a and insulin genes. Nkx6.1 is considered to be a highly specific transcription factor marking pancreatic beta islet cells, where it is expressed in both developing and mature cells. In addition, Nkx6.1 functions as a transcriptional repressor induced by the Sonic Hedgehog (Shh) signaling pathway in fate determination of several neuronal cell types. During antibody development, the purified R11-560 monoclonal antibody was found to detect Nkx6.1 by western blot and indirect immunofluorescent staining followed by flow cytometric analysis or imaging analysis.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Nkx6.1, NKX6-1, NKX6A, Nkx6-1, Nkx6.1, Nkx6a|
|Human Nkx6.1 Recombinant Protein|
|Store undiluted at 4°C|