NME1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528794

Catalog No. PIPA528794

Description

PA5-28794 targets nm23-H1 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28794 immunogen is synthetic peptide corresponding to a region within amino acids 89 and 152 of Human nm23-H1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of  ft.A ft. (encoded by this gene) and  ft.B ft. (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Specifications

• Antigen: NME1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NME1
• Format: Liquid
• Gene Symbols: NME1
• Immunogen: Synthetic peptide corresponding to a region within amino acids 89 and 152 of Human nm23-H1
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.98 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P15531
• Gene Alias: AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, NDP kinase A, granzyme A-activated DNase, metastasis inhibition factor nm23, nucleoside diphosphate kinase A, tumor metastatic process-associated protein
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μL
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 4830