noggin, Mouse, Clone: 4C9, Abnova™

Catalog No.	Quantity
89-001-122	100 μg

Catalog No. 89-001-122 Supplier Abnova Corporation Supplier No. H00009241M01

Description

Mouse monoclonal antibody raised against a full-length recombinant NOG.

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq

Sequence: QHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

Specifications

• Antigen: noggin
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 4C9
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a full length recombinant NOG.
• Formulation: PBS with no preservative; pH 7.4
• Gene: NOG
• Gene Accession No.: BC034027
• Gene Alias: SYM1/SYNS1
• Gene Symbols: NOG
• Host Species: Mouse
• Immunogen: NOG (AAH34027, 28 a.a. ∼ 232 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neurobiology
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 9241
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG2b κ