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NOTUM Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112858

Catalog No. 01-675-838


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Description

Description

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/β-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

A suggested positive control for this product is HepG2 cell lysate.
Specifications

Specifications

Notum
Polyclonal
Unconjugated
NOTUM
Liquid
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
147111, 77583
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q6P988, Q8R116
NOTUM
Recombit full-length notum protein from mouse.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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