NPAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520364
A suggested positive control is SK-N-SH cell lysate. PA5-20364 can be used with blocking peptide PEP-0484.Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
|a 28 amino acid peptide from near the amino terminus of human NPAS3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|MOP6, PASD6, bHLHe12; PAS domain-containing protein 6; basic-helix-loop-helix-PAS protein MOP6; class E basic helix-loop-helix protein 12; member of PAS protein 6; neuronal PAS domain-containing protein 3; neuronal PAS3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|27386, 299016, 64067|
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