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NPM-ALK/ALK Mouse anti-Human, Unlabeled, Clone: ALK1, BD

Catalog No. BDB559254 Shop All BD Biosciences Products
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BDB559254 0.1 mg
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Catalog No. BDB559254 Supplier BD Biosciences Supplier No. 559254

Description

Mouse Monoclonal Antibody

Reacts with NPM-ALK, a chimeric gene product of approximately 80kDa, which is the result of t(2;5)(p23;q35) chromosomal translocation. The gene at 5q35 encodes for the cell cycle-regulated nuclolar protein nucleophosmin (NPM), and the gene at 2p23 encodes a novel receptor tyrosine kinase, anaplastic lymphoma kinase (ALK). The 2;5 translocation results in the expression of NPM-ALK protein, or p80, comprised of the N-terminal portion of NPM (about 40% of the molecule) linked to the entire intracellular portion of ALK. ALK1 antibody recognizes a formalin resistant epitope in both the NPM-ALK chimeric and the 200kDa normal human ALK proteins. Cytoplasmic and nuclear expression of NPM-ALK is seen in t(2;5)+ cell lines SU-DHL-1 and Karpas 299. This antibody is routinely tested by flow cytometric analysis and fluorescence microscopy. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen NPM-ALK/ALK
Applications Flow Cytometry
Classification Monoclonal
Clone ALK1
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen x
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG3 κ
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