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MilliporeSigma™ anti-NRF-1 Clone: R157.1.3H3,

Catalog No. MABE995MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE995MI 100 μg Unconjugated
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Catalog No. MABE995MI Supplier MilliporeSigma™ Supplier No. MABE995
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Description

Mouse Monoclonal Antibody

Specifically detects NRF-1 Clone: R157.1.3H3 in Human samples, and it is validated for ChIP, ChIP-seq, Chromatin Immunoprecipitation, Western Blotting

Nuclear respiratory factor 1 (UniProt Q16656; also known as Alpha-pal, Alpha palindromic-binding protein, NRF-1) is encoded by the NRF1 (also known as ALPHA-PAL) gene (Gene ID 4899) in human. NRF-1 is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. NRF-1 is upregulated and activated/phosphorylated by Akt in response to oxidant exposure or increased cellular reactive oxygen species (ROS), resulting in NRF-1 nuclear translocation, where it binds to DNA as a homodimer and mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRF-1
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot, Western Blot
Classification Monoclonal
Clone R157.1.3H3
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q16656
Gene Symbols NRF1
Host Species Mouse
Immunogen Recombinant protein corresponding to human NRF-1.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001035199
Target Species Human
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2a κ
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For Research Use Only

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