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NUP107 Mouse anti-Bovine, Chicken, Drosophila, Equine, Human, Mouse, Porcine, Rat, Yeast, Clone: 39C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110031

Catalog No. 01-670-288


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Description

Description

For immunofluorescence on yeast cells, try MCA-39C7 diluted 1:100 to 1:500. For immunofluorescence on mammalian cells try at 1:50 to 1:100.

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
Specifications

Specifications

NUP107
Monoclonal
Unconjugated
NUP107
Liquid
NUP107
Yeast nuclear preparation.
500 μL
Store at 4°C short term. For long term storage, Store at -20°C, avoiding freeze/thaw cycles.
Primary
100059287, 100516909, 101751988, 103468, 116555, 34481, 504823, 57122
Immunocytochemistry, Immunofluorescence
39C7
tissue culture supernatant with no preservative
P52590, P57740, Q8BH74, Q9V466
AW541137, C76801
Mouse
IgG1
RUO
Antibody
Monoclonal
Bovine, Chicken, Drosophila, Equine, Human, Mouse, Porcine, Rat, Yeast
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