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NUMB Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521143

Catalog No. PIPA521143


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Description

Description

A suggested positive control is mouse lung tissue lysate. PA5-21143 can be used with blocking peptide PEP-1257.

NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determit NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
Specifications

Specifications

NUMB
Polyclonal
Unconjugated
NUMB
Liquid
NUMB
A 17 amino acid peptide near the carboxy terminus of human NUMB.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P49757, Q9QZS3, Q2LC84
C14orf41, S171; h-Numb; protein numb homolog
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
18222, 29419, 8650
Documents
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