NUMB Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521143
A suggested positive control is mouse lung tissue lysate. PA5-21143 can be used with blocking peptide PEP-1257.NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determit NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
|A 17 amino acid peptide near the carboxy terminus of human NUMB.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P49757, Q9QZS3, Q2LC84|
|C14orf41, S171; h-Numb; protein numb homolog|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|18222, 29419, 8650|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok