Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Occludin Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611090

 View more versions of this product

Catalog No. BDB611090

Add to cart



Tight junctions (zonulae occludens) are critical to the maintenance of cell polarity and intercellular barriers between epithelial and endothelial cells. Among the barriers formed by the tight junctions is the critical blood-brain barrier. Protein components of the tight junctions include actin filaments, symplekin, occludin, Rab3B, AF-6, 7H6, ZO-1 and ZO-2. The human occludin protein is 522 amino acids with four transmembrane domains in the first half of the protein. Two glycine/tyrosine-rich extracellular loops are involved in cell-cell interactions. In the cytoplasm, occludin interacts with ZO-1 through its intracellular C-terminus. A possible function of ZO-1 may be to link the adherens components, like occludin, to the submembraneous actin cytoskeleton. Experimental breakdown of the tight junctions at the blood-brain barrier results in redistribution of vinculin and loss of ZO-1 and Occludin. Taken together, these data indicate that occludin and ZO-1 are critical elements in the formation of tight junctions and may also serve an important role in signaling and tumor suppression.


Affinity Purified
Mouse Occludin aa. 396-507
Cell Biology
Canine, Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.