Oct-2 Rat, Unlabeled, Clone: 9A2, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 562837
The 9A2 monoclonal antibody specifically binds to Oct-2 that has a molecular weight of approximately 50-60 kDa. The 9A2 antibody was generated against the 44 N-terminal amino acids common to mouse Oct-2 isoforms and crossreacts with both human and mouse Oct-2. Oct-2 is a POU class 2 homeobox 2 transcription factors (POU2F2) that is also known as OCT2, OTF2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 and Octamer-binding transcription factor 2. The POU domain in the Oct-2 protein is required for low and high affinity cooperative binding of the octomer sequence and heptamer site in immunoglobulin promoters and promoters for other genes. Oct-2 is expressed in B cells, activated CD4+ and CD8+ T cells, monocytes/macrophages and subsets of dendritic cells. Oct-2 is reportedly associated with neoplasms including Diffuse Large B-cell lymphoma and Nodular Lymphocyte predominant Hodgkin's lymphoma. Studies with knockout mouse models suggest Oct-2 is required for B cell maturation, but not for B cell commitment, and for B cell production of IL-6.
Host Species: Rat
Isotype: IgG2a, κ
Species Reactivity: Hu, Ms
Immunogen: Mouse Oct-2 amino acids 1-44 Recombinant Protein
Flow Cytometry, Intracellular Staining, Western Blotting
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Oct2, OTF-2, OCT2, OTF2, Oct2, NF-A2, POU2F2, Pou2f2, Otf2|
|Mouse Oct-2 amino acids 1-44 Recombinant Protein|
|Store undiluted at 4°C|
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