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Oct3/4 (Human Isoform A) Mouse, Alexa Fluor 647, Clone: O50-808, BD

Catalog No. BDB562252 Shop All BD Biosciences Products
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BDB562252 50 Tests
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Catalog No. BDB562252 Supplier BD Biosciences Supplier No. 562252

Description

Mouse Monoclonal Antibody

Development of a multicellular organism from a single fertilized egg is regulated by the coordinated activity of DNA transcription factors. Oct3/4, a member of the POU family of transcription factors, functions in pluripotent cells of early embryonic stem (ES) cell lines and embryonal carcinomas (EC). The human POU5F1 gene can encode various splice variants, two of which are Oct3/4A and Oct3/4B. Both isoforms share identical POU DNA-binding and C-terminal domains but differ in their N-terminal domain. The N-terminal domain of Oct3/4B is inhibitory to the DNA binding domain and therefore cannot stimulate transcription of Oct3/4-dependent genes. Oct3/4B can be detected in both pluripotent and some differentiated cell types in both the nucleus and cytoplasm, but its function is unclear. There is not an equivalent to Oct3/4B in mouse. Oct3/4A is expressed in the nucleus and has been demonstrated to orchestrate the transcription of Oct3/4-dependent genes. It has been demonstrated that the expression of Oct3/4 isoforms can vary greatly in different cell types, and discrimination of these is crucial for assessing Oct3/4 expression and function. The O50-808 monoclonal antibody recognizes human Oct3/4 Isoform A and mouse Oct3/4.

Host Species: Mouse
Clone: O50-808
Isotype: IgG1, κ
Species Reactivity: Human
Immunogen: Human Oct3/4 Isoform A Recombinant Protein

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen Oct3/4 (Human Isoform A)
Applications Flow Cytometry
Classification Monoclonal
Clone O50-808
Conjugate Alexa Fluor 647
Description Oct3/4A, Oct-3A, OTF-3, NF-A3, OTF4, POU5F1, MGC22487
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Oct3/4 Isoform A Recombinant Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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