OPRK1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3028
IHC (P) analysis shows positive staining of KOR in human brain. WB analysis shows KOR in glycoprotein-enriched fractions from mock transfected or KOR overexpressing 293 cells. While KOR has a theoretical MW of ~ 43kD, the observed band in a WB runs at ~60kD due to enrichment of the glycosylated receptor.The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. G-protein coupled opioid receptor functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. KORs are widely distributed in the brain, spinal cord and pain neurons.
|whole serum with 0.05% sodium azide|
|Opioid Receptor Kappa, Opioid Receptor Kappa 1, Kappa Opioid Receptor, KOR, K-OR-1, KOR-1, KOPR1, OPRK, Kappa-Type Opioid Receptor|
|Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated Cys-RVRNTVQDPAYLRDIDGMNKPV|
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