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Osteopontin Chicken anti-Human, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA172061

Catalog No. PA172061


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Description

Description

PA1-72061 detects Osteopontin-c in human samples. PA1-72061 has been successfully used in ELISA procedures. The PA1-72061 immunogen is a peptide representing the splice junction of osteopontin-c (Ac-SEEKQNAVSC-COOH).

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Specifications

Specifications

Osteopontin
Polyclonal
Unconjugated
SPP1
Liquid
SPP1
Synthetic peptide corresponding to the splice junction of osteopontin-c.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Western Blot
2 mg/mL
PBS with 0.075% sodium azide; pH 7.2
P10451
BNSP, BSPI, ETA-1, MGC110940, OPN
Chicken
IgY
100 μg
4° C
Primary
6696
Documents
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