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P-glycoprotein Mouse anti-Human, PE, Clone: 17F9, BD

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BDB557003 100 Tests
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Catalog No. BDB557003 Supplier BD Biosciences Supplier No. 557003
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Description

Mouse Monoclonal Antibody

Reacts with a 170-180kDa transmembrane glycoprotein (P-glycoprotein), a product of the multidrug resistance-1 (MDR1) gene. This glycoprotein is expressed on MDR positive cells and has been reported to be expressed on many normal tissues, such as adrenal glands and endothelium, in the brain and skin. P-glycoprotein is known to impart drug resistance to cells by pumping many anti-cancer drugs out of the cytoplasm. 17F9 antibody binds to the surface of the viable, unfixed MDR+ cell line, PMG-Y (please inquire), and is able to partially block the binding of UIC2 antibody (another MDR-specific monoclonal antibody). Immunoprecipitation application is reported, but not routinely tested in house.

Host Species: Mouse
Clone: 17F9
Isotype: IgG2b, κ
Cross Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen P-glycoprotein
Applications Flow Cytometry
Classification Monoclonal
Clone 17F9
Conjugate PE
Description CD243; ABCB1; ABC20; CLCS; GP170; MDR1; P-GP; PGY1
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human MDR1 Transfected Cell Line
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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