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p120 Catenin (pT310) Mouse anti-Human, PE, Clone: 22/P120 (PT310), BD

Catalog No. BDB558596 Shop All BD Biosciences Products
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BDB558596 50 Tests
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Catalog No. BDB558596 Supplier BD Biosciences Supplier No. 558596

Description

Mouse Monoclonal Antibody

The membrane-associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src-transformed cells. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like β- and γ-catenin, p120 catenin directly associates with the cytoplasmic C terminus of E-Cadherin via its Arm domain. It exists as four isoforms that range in size from 90 to 115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S873) and threonine (T310 and T910) residues in p120 catenin may regulate its activity. The S873 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b. Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation. The 22/p120 (pT310) monoclonal antibody recognizes the phosphorylated T310 in the regulatory domain of p120 catenin.

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen p120 Catenin (pT310)
Applications Flow Cytometry
Classification Monoclonal
Clone 22/P120 (PT310)
Conjugate PE
Host Species Mouse
Immunogen Phosphorylated Human p120 Catenin Peptide
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Isotype IgG1
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