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p130Cas (pY249) Mouse anti-Human, Unlabeled, Clone: J169-757.12.2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558401

Catalog No. BDB558401


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Description

Description

p47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-Crk protein is a fusion product of viral Gag protein and a part of cellular Crk that includes SH2 and SH3 domains. v-Crk-induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130Cas (CRK-associated substrate). The p130Cas is tightly associated with v-Crk via the SH2 domain of v-Crk. Tyrosine phosphorylation of p130Cas occurs in conjunction with cellular transformation in cells that express v-Src or v-Crk. This phosphorylation leads to a change in p130Cas localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130Cas also associates with v-Src, it may be a v-Src substrate. Several phosphorylation sites have been described in p130Cas upon Fibroblast Growth Factor stimulation, and phosphorylated tyrosine (Y249) might function as a binding site for the Crk-adaptor molecule. The J169-757.12.2 monoclonal antibody recognizes the phosphorylated Y249 of human p130Cas. The orthologous phosphorylation sites in mouse and rat p130Cas are Y253 and Y347, respectively.

Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

p130Cas (pY249)
Monoclonal
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Phosphorylated Human p130Cas
0.1 mg
Cell Biology
Human
IgG2b κ
Western Blot
J169-757.12.2
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C
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