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p27 Rabbit anti-Mouse, Unlabeled, Polyclonal, BD

Catalog No. BDB558902 Shop All BD Biosciences Products
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BDB558902 0.1 mL
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Catalog No. BDB558902 Supplier BD Biosciences Supplier No. 558902

Description

Rabbit Polyclonal Antibody

p27 (Kip1) is a cyclin-dependent kinase inhibitor (cdkI) that associates with cyclin/cdk complexes to inhibit their catalytic activity. p27 was first identified as a result of its role in TGF-β-induced G1 phase arrest and cell-cell contact. In vitro, p27 binds tightly to cyclin D-Cdk4, cyclin E-Cdk2, and cyclin A-Cdk2 complexes to inhibit their activity. In non-dividing cells, the level of p27 is elevated and its activity gradually decreases as cells reach S phase. Mitogenic stimulation causes the cyclin D-CDK complex to bind and sequester p27. An increase in Cdk2 activity during G1 causes the degradation of p27. Phosphorylation of p27 is necessary for its degradation and is mediated by the SCF complex (Skp1,2/Cdc53 (cullins))/F-box proteins. SCF complexes are involved in targeting phosphorylated proteins for ubiquitin-dependent proteolysis. The antibodies recognize mouse p27. A peptide coupled to KLH and corresponding to amino acids 184-197 at the C-terminus of mouse p27 was used as immunogen.

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen p27
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Clone POLYCLONAL
Conjugate Unconjugated
Host Species Rabbit
Immunogen Mouse p27 aa. 184-197 peptide
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse
Form Serum
Isotype IgG
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