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  6. p38 MAPK (pT180/pY182) Mouse, Unlabeled, Clone: 36/P38 (PT180/PY182), BD

p38 MAPK (pT180/pY182) Mouse, Unlabeled, Clone: 36/P38 (PT180/PY182), BD

Catalog No. BDB612288 Shop All BD Biosciences Products
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BDB612289 150 μg
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Description

Mouse Monoclonal Antibody

Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-α. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). MAPK signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases include p38α, β, γ, and δ. These ser/thr kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-κB, ATF-2, Elk-1, and CHOP) that induce expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in muliple signal transduction pathways.

Immunofluorescence, Intracellular Staining, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen p38 MAPK (pT180/pY182)
Applications Western Blot
Classification Monoclonal
Clone 36/P38 (PT180/PY182)
Concentration 250μg/mL
Conjugate Unconjugated
Description MAPK14; p38 MAP kinase; p38 MAPK; RK; CSBP2
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human p38 MAPK (pT180/pY182) Peptide
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1 κ
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For Research Use Only.

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