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p53 Mouse anti-Human, Unlabeled, Clone: DO-7, BD

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BDB554294 0.1 mg
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Catalog No. BDB554294 Supplier BD Biosciences Supplier No. 554294
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Description

Mouse Monoclonal Antibody

p53 is a 53kDa nuclear phosphoprotein that acts as a tumor suppressor protein, and is involved in inhibiting cell proliferation when DNA damage occurs. The gene for p53 is the most commonly mutated gene yet identified in human cancers. Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is overexpressed in a variety of transformed cells and wildtype p53 forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus, and E6 from human papilloma virus. Wildtype p53 plays a role as a checkpoint protein for DNA damage during the G1/S-phase of the cell cycle. However, it is still unclear, whether point mutated forms of p53 are simple null mutants and/or dominant negatively acting proteins. The DO-7 antibody recognizes human wildtype and mutant p53. It cross-reacts with bovine p53 but does not cross-react with mouse or rat p53. DO-7 recognizes an epitope between amino acids 1-45 of known forms of human p53. Human recombinant p53 protein was used as immunogen. Wildtype 53 proteins have a very short half-life and are usually not detectable with monoclonal antibodies (mAbs) in normal tissues.

Host Species: Mouse
Clone: DO-7
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human Recombinant p53 protein
Formula Weight [Chemical]: 53kDa

Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen p53
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone DO-7
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Recombinant p53 protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Bovine, Human, Monkey
Content And Storage Store undiluted at 4°C
Isotype IgG2b
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For Research Use Only.

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