p53 Mouse anti-Human, Unlabeled, Clone: G59-12, BD

Catalog No.	Quantity
BDB554157	0.1 mg

Catalog No. BDB554157 Supplier BD Biosciences Supplier No. 554157

Description

Mouse Monoclonal Antibody

p53 is a 53kDa nuclear phosphoprotein that acts as a tumor suppressor protein, and is involved in inhibiting cell proliferation when DNA damage occurs. The gene for p53 is the most commonly mutated gene yet identified in human cancers. Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is overexpressed in a variety of transformed cells and the wildtype p53 forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus and E6 from human papilloma virus. Wildtype p53 plays a role as a checkpoint protein for DNA damage during the S-phase of the cell cycle. p53 migrates at a reduced molecular weight of 53kDa. Clone G59-12 recognizes mutant and wild type human, rat and mouse p53 tumor suppressor protein. Recombinant full-length human p53 was used as immunogen.

Host Species: Mouse
Clone: G59-12
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Recombinant full-length human p53
Formula Weight [Chemical]: 53kDa

Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting

Specifications

• Antigen: p53
• Applications: Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: G59-12
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Recombinant full-length human p53
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.