p53 Mouse anti-Human, Unlabeled, Clone: G59-12, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 554157

Catalog No. BDB554157

Description

p53 is a 53kDa nuclear phosphoprotein that acts as a tumor suppressor protein, and is involved in inhibiting cell proliferation when DNA damage occurs. The gene for p53 is the most commonly mutated gene yet identified in human cancers. Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is overexpressed in a variety of transformed cells and the wildtype p53 forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus and E6 from human papilloma virus. Wildtype p53 plays a role as a checkpoint protein for DNA damage during the S-phase of the cell cycle. p53 migrates at a reduced molecular weight of 53kDa. Clone G59-12 recognizes mutant and wild type human, rat and mouse p53 tumor suppressor protein. Recombinant full-length human p53 was used as immunogen.

Host Species: Mouse
Clone: G59-12
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Recombinant full-length human p53
Formula Weight [Chemical]: 53kDa

Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blotting

Specifications

• Antigen: p53
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Recombinant full-length human p53
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

• Applications: Flow Cytometry, Western Blot
• Clone: G59-12
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.