Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

p53 Mouse, Unlabeled, Clone: PAB 122, BD

Mouse Polyclonal Antibody

Supplier:  BD Biosciences 554147

Catalog No. BDB554147


Only null left
Add to Cart

Description

Description

The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers.1 Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is overexpressed in a variety of transformed cells and it forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus, and E6 from human papilloma virus. Wild type p53 plays a role as a checkpoint protein for DNA damage during the G1/S-phase of the cell cycle. However, it is still unclear, whether point mutated forms of p53 are simple null mutants and/or dominant negatively acting proteins. p53 migrates at a reduced molecular weight of 53kDa. PAb 122 recognizes mammalian p53, including mouse, rat, hamster, monkey and human p53.2 Cells from the SV40-transformed mouse cell line BALB/c 3T3 clone 4 (B4) were used as immunogen. PAb 122 was originally evaluated by ELISA, immunoprecipitation, radioimmunoassays and indirect immunofluorescence of cultured cells.

Host Species: Mouse
Clone: PAb 122
Isotype: IgG2b
Species Reactivity: Monkey
Immunogen: SV40-transformed mouse cell line BALB/c 3T3 clone 4 (B4)
Formula Weight [Chemical]: 53kDa

Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

p53
Polyclonal
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
SV40-transformed mouse cell line BALB/c 3T3 clone 4 (B4)
0.1 mg
Cell Biology
Hamster, Human, Monkey, Mouse, Rat
IgG2b
Western Blot
PAB 122
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.

For Research Use Only.