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MilliporeSigma™ anti-p53 (Mutant) Clone: PAb240,

Catalog No. OP29L100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
OP29L100UG 100 μg Unconjugated
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Catalog No. OP29L100UG Supplier MilliporeSigma™ Supplier No. OP29L100UG
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Description

Mouse Monoclonal Antibody

Specifically detects p53 (Mutant) Clone: PAb240 in Bovine, Chicken, Hamster, Human, Mouse, Rat samples, and it is validated for Flow Cytometry, Gel Supershift, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting

The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage. This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes. The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p53 (Mutant)
Applications Flow Cytometry, Gel Supershift, Immunoblot, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Clone PAb240
Conjugate Unconjugated
Formulation In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Host Species Mouse
Immunogen a recombinant protein consisting of amino acids 14-389 of p53 fused to β-galactosidase
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽53kDa mutant p53 protein under non-denaturing conditions by immunoprecipitation, immunofluorescence, and flow cytometry. Recognizes both mutant and wild-type p53 by immunoblotting and paraffin sections under denaturing conditions.
Target Species Bovine, Chicken, Hamster, Human, Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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