p53 with control Mouse, PE, Clone: G59-12, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 557027

Catalog No. BDB557027

Description

p53 is a 53 kD nuclear phosphoprotein that acts as a tumor suppressor protein, and is involved in inhibiting cell proliferation when DNA damage occurs. The gene for p53 is the most commonly mutated gene yet identified in human cancers. Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs. The mutant p53 is overexpressed in a variety of transformed cells and wild-type p53 forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus, and E6 from human papilloma virus. Wild type p53 plays a role as a checkpoint protein for DNA damage during the G1/S-phase of the cell cycle.

G59-12 recognizes mutant and wild type human, rat and mouse p53 tumor suppressor protein. Recombinant full-length human p53 was used as immunogen. The G59-12 clone was originally characterized by western blot analysis, immunoprecipitation and immunohistochemical staining. Clone MOPC-21 is a mouse IgG1 isotypecontrol. The MOPC-21 antibody has unknown specificity.

Specifications

• Antigen: p53 with control
• Classification: Monoclonal
• Conjugate: PE
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Includes: PE Mouse Anti-p53 (100 tests), PE Mouse IgG1, κ Isotype Control (100 tests)
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: G59-12
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.